|
|||||
|
|
Synthesis of fused bicyclic glutarimides |
|
| Authors: | Meng-Yang Chang Chung-Yi ChenShui-Tein Chen Nein-Chen Chang |
| Affiliation: | a Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung 811, Taiwan, ROC b Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC c Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan, ROC |
| Abstract: | We describe an efficient route towards the synthesis of fused bicyclic glutarimides using facile [3+3] reaction of α-sulfonylacetamides with different α,β-unsaturated esters as the key step. Intramolecular cyclization of 4-substituted 3-sulfonylglutarimide to form 5,6-, 6,6- or 6,7-fused bicyclic glutarimides was accomplished via alkylation, oxidative cyclization or ring-closing metathesis in modest yield. |
| Keywords: | bicyclic glutarimides stepwise [3+3] annulation intramolecular alkylation oxidative cyclization or ring-closing metathesis |
| 本文献已被 ScienceDirect 等数据库收录！ | |