On the reactivity of ascomycin at the binding domain. Part 1: Liberation of the tricarbonyl portion of ascomycin |
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| Authors: | Karl Baumann Markus BacherAnnelaure Damont Klemens HögenauerAndrea Steck |
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| Institution: | Department of Medicinal Chemistry, Novartis Research Institute Vienna, Brunnerstrasse 59, A-1235 Vienna, Austria |
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| Abstract: | Within the binding domain, ascomycin features the unusual pattern of a masked tricarbonyl moiety, which potentially allows for high structural diversity via simple isomerisation events. Herein, methodologies, allowing the liberation of the tricarbonyl unit by blocking the 14-hydroxy group are reported. |
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| Keywords: | ascomycin binding domain tricarbonyl portion |
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