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Total synthesis of the polyenoyltetramic acid polycephalin C |
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| Authors: | Deborah A LongbottomAngus J Morrison Darren J DixonSteven V Ley |
| Institution: | Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK |
| Abstract: | The total synthesis of the polyenoyltetramic acid polycephalin C is described. Key steps of the synthesis include a double Swern oxidation, double Takai reaction and a double Stille reaction. In addition, the absolute stereochemistry of the ring junction has been determined by synthesis of both isomers and comparison of their CD spectra with natural polycephalin C. |
| Keywords: | natural product synthesis tetramic acids lactams Takai reaction Swern oxidation |
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