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Polyhydroxy pregnanes from Dregea volubilis
Authors:Nilendu PandaNirup B Mondal  Sukdeb BanerjeeNiranjan P Sahu  Kazuo KoikeTamotsu Nikaido  Manuela WeberPeter Luger
Institution:a Steroid and Terpenoid Chemistry Division, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, India
b Department of Biomedical Sciences, School of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan
c Free University of Berlin Institut for Chemistry/Crystallograhy Frei Universität Berlin, Institut für Chemie/Kristallographie, Takustr. 6, D-14195 Berlin, Germany
Abstract:Three new polyhydroxy pregnanes named dregealol (1), volubilogenone (2) and volubilol (3) were isolated from the flowers of Dregea volubilis, and their structures elucidated from extensive 2D NMR analysis. The structure of volubilol (3) was confirmed by X-ray crystallographic studies. The known pregnane derivatives drevogenin D, iso-drevogenin P and 17α-marsdenin were also isolated.
Keywords:Dregea volubilis  polyhydroxy pregnane  dregealol  volubilogenone  volubilol  iso-drevogenin P  17α-marsdenin  drevogenin D  2D NMR  X-ray analysis
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