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Five novel norcembranoids from Sinularia leptoclados and S. parva |
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| Authors: | Atallah F Ahmed Ru-Ting ShiueGuey-Horng Wang Chang-Feng DaiYao-Haur Kuo Jyh-Horng Sheu |
| Institution: | a Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC b Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt c Institute of Oceanography, National Taiwan University, Taipei 106,Taiwan, ROC d National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC |
| Abstract: | Three new norcembrane-based diterpenoids, leptocladolides A (1), B (4) and C (5), along with five known metabolites 6-10, have been isolated from the dichloromethane extract of a Taiwanese soft coral Sinularia leptoclados. Furthermore, a chemical investigation on the dichloromethane extract of S. parva has resulted in the isolation of two new related isomers, 1-epi-leptocladolide A (2) and 7E-leptocladolide A (3), in addition to 1 and 7. The structures of new metabolites 1-5 were elucidated on the basis of extensive spectroscopic analyses and their relative stereochemistries were determined by NOESY experiments. The new metabolites 1 and 3 have been shown to exhibit significant cytotoxic activity against KB and Hepa59T/VGH cancer cell lines. |
| Keywords: | Sinularia leptoclados S parva leptocladolide A-C 1-epi-leptocladolide 7E-leptocladolide soft coral |
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