Application of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry in human metabolomic studies |
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| Authors: | Jitka Zrostlikova Joe Binkley Petr Wojtowicz Tomas Adam |
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| Affiliation: | 1.Application Laboratory Prague,LECO Corp.,Prague,Czech Republic;2.Application Laboratory Prague,LECO Corp.,St. Joseph,USA;3.Laboratory of Inherited Metabolic Disorders,Palacky University Olomouc,Olomouc,Czech Republic |
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| Abstract: | In this paper several characteristic features of time-of-flight mass spectrometry in coupling with gas chromatography are demonstrated and the parameters are compared to quadrupole mass analyzer. In the second part, the comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry was applied in human metabolomic field, particularly in the determination of pathological markers of Inherited Metabolic Disorders (IMDs). |
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