| 利用Diels-Alder反应构建桉烷类倍半萜骨架关键中间体的研究 |
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| 引用本文： | 张宇,王鹏辉,楚勇,刘明明,陈广怡,陆银萍,叶德泳.利用Diels-Alder反应构建桉烷类倍半萜骨架关键中间体的研究[J].有机化学,2012,32(7):1340-1343. |
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| 作者姓名： | 张宇 王鹏辉 楚勇 刘明明 陈广怡 陆银萍 叶德泳 |
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| 作者单位： | 复旦大学药学院药物化学教研室 上海201203 |
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| 基金项目： | 国家自然科学基金，创新药物平台 |
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| 摘 要： | 以3-甲基-1,3-间苯二酚和异戊醛为原料分别合成亲双烯2-甲氧基-6-甲基对苯醌和双烯1-甲氧基-3-异丙基-1,3-丁二烯,通过Diels-Alder反应,高区域选择性地得到桉烷类倍半萜骨架中间体2c.
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| 关 键 词： | Diels-Alder反应 桉烷 倍半萜 区域选择性 |
Studies on Constructing of the Key Intermediate of Eudesmane Sesquiterpenoid Analogues via Diels-Alder Reaction |
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| Zhang,Yu
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Wang,Penghui
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Chu,Yong
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Liu,Mingming
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Chen,Guangyi
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Lu,Yinping
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Ye,Deyong.Studies on Constructing of the Key Intermediate of Eudesmane Sesquiterpenoid Analogues via Diels-Alder Reaction[J].Chinese Journal of Organic Chemistry,2012,32(7):1340-1343. |
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| Authors: | Zhang Yu Wang Penghui Chu Yong Liu Mingming Chen Guangyi Lu Yinping Ye Deyong |
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| Institution: | Zhang,Yu Wang,Penghui Chu,Yong Liu,Mingming Chen,Guangyi Lu,Yinping Ye,Deyong(Department of Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203) |
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| Abstract: | The key intermediate of eudesmane sesquiterpenoid analogue 2c was synthesized with high regioselectivity via Diels-Alder reaction from the dienophile 2-methoxyl-6-methyl-1,4-benzoquinone and the diene 1-methoxyl-3-isopropyl-1,4-butadiene. |
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| Keywords: | Diels-Alder reaction eudesmane sesquiterpenoid regioselectivity |
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