Pseuduvarines A and B, two new cytotoxic dioxoaporphine alkaloids from Pseuduvaria rugosa |
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| Authors: | Taha Hairin Hadi A Hamid A Nordin Noraziah Najmuldeen Ibrahim A Mohamad Khalit Shirota Osamu Nugroho Alfarius E Piow Wong Chin Kaneda Toshio Morita Hiroshi |
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| Institution: | Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia. moritah@hoshi.ac.jp |
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| Abstract: | Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC??, 0.9, 21.7, and >50.0 μM, respectively, 2: IC?? >50.0, 15.7, and 12.4 μM, respectively). |
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