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Screening and docking studies of natural phenolic inhibitors of carbonic anhydrase Ⅱ
基金项目:Supported by the National Natural Science Foundation of China (Grant No. 30725048);;the Foundation of Chinese Academy of Sciences (West Light Program)
摘    要:Carbonic anhydrase Ⅱ (CAⅡ) is an important enzyme complex with Zn2+,which is involved in many physiological and pathological processes, such as calcification, glaucoma and tumorigenicity. In order to search for novel inhibitors of CAⅡ, inhibition assay of carbonic anhydrase Ⅱ was performed, by which seven natural phenolic compounds, including four phenolics (grifolin, 4-O-methyl-grifolic acid, grifolic acid, and isovanillic acid) and three flavones (eriodictyol, quercetin and puerin A), showed in-hibitory a...

关 键 词:carbonic  anhydraseⅡ  natural  inhibitors  screening  docking  
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