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Palladium-catalyzed copper(I)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling |
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| Authors: | Singh Brajendra Kumar Mehta Vaibhav Pravinchandra Parmar Virinder Singh Van der Eycken Erik |
| Affiliation: | Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001, Heverlee/Leuven, Belgium. |
| Abstract: | The application of a palladium-catalyzed Cu(I)-mediated Liebeskind-Srogl protocol for the decoration of the 2(1H)-pyrazinone scaffold resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling. |
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