Mannich Synthesis of Acetylenic Amino Alcohols in Aqueous Ionic Liquids |
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| Authors: | Nina I Simirskaya Nikolai V Ignat’ev Michael Schulte Sergei G Zlotin |
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| Institution: | 1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;2. Merck KGaA, PM-ABE, D-64293 Darmstadt, Germany |
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| Abstract: | Terminal alkynols react with formaldehyde and secondary amines in aqueous ionic liquid emim]HSO–4 in the presence of Cu(OAc) to afford the corresponding 1-(a-hydroxyalkyl)- or 1-(b-hydroxyalkyl)-2-(aminomethyl)acetylenes in better yields in comparison with the reaction in conventional organic solvents. The catalytic system can be easily recovered and recycled. |
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