| (Z)-3-丁烯基-4-羟基苯酞的合成 |
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| 引用本文： | 李绍白,王志伟,方小平,李裕林.(Z)-3-丁烯基-4-羟基苯酞的合成[J].高等学校化学学报,1995,16(4):582. |
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| 作者姓名： | 李绍白 王志伟 方小平 李裕林 |
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| 作者单位： | 兰州大学应用有机化学国家重点实验室, 兰州, 730000 |
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| 摘 要： | （Ｚ）－３－丁烯基－４－羟基苯酞的合成李绍白，王志伟，方小平，李裕林（兰州大学应用有机化学国家重点实验室，兰州，７３００００）关键词（Ｚ）－３－丁烯基－４－羟基苯酞，苯酞，３－丙基－５－羟基异香豆素，异香豆素，合成（Ｚ）－３－丁烯基－４－羟基苯酞（１...
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| 关 键 词： | (Z)-3-丁烯基-4-羟基苯酞 苯酞 3-丙基-5-羟基异香豆素 异香豆素 合成 |
| 收稿时间： | 1994-05-12 |
Synthesis of (Z)-3-Butylidene-4-hydroxyphthalide |
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| LI Shao-Bai,WANG Zhi-Wei, FANG Xiao-Ping,LI Yu-Lin.Synthesis of (Z)-3-Butylidene-4-hydroxyphthalide[J].Chemical Research In Chinese Universities,1995,16(4):582. |
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| Authors: | LI Shao-Bai WANG Zhi-Wei FANG Xiao-Ping LI Yu-Lin |
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| Institution: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 |
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| Abstract: | Z)-3-Butylidene-4-hydroxyphthalide(1)was prepared from 2-formyl-3-methoxy benzoic acid(2).2 was converted to 2-pentenyl-3-methoxybenzoic acid(4)by the usual method.4 was dissolved in sodium bicarbonate solution and reacted with a solution of iodine in aqueous potassium iodide to give 5 and 6,which was converted to 3-propyl-5-hydroxyiso coumarine(3)by the conventional method.Iodophthalide(5)was treated with sodium acetate to furnish(Z)-3-butylidene-4-methoxyphthalide(7).Demethylation of 7 was conducted with boron tribromide to give the title compound(1).The overall yield of 1 is 46%. |
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| Keywords: | Z)-3-Butylidene-4-hydroxyphthalide Phthalide 3-Propyl-5-hydroxyiso-Coumarin Isocoumarin Synthesis |
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