Structural-morphological and biological properties of selenium nanoparticles stabilized by bovine serum albumin |
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| Authors: | S V Valueva L N Borovikova V V Koreneva Ya I Nazarkina A I Kipper V V Kopeikin |
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| Institution: | (1) Institute of High-Molecular Weight Compounds, Russian Academy of Sciences, St. Petersburg, Russia;(2) Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia |
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| Abstract: | Nanostructures formed during the reduction of ionic selenium in the selenite-ascorbate redox system in an aqueous solution of bovine serum albumin (BSA) were studied using static and dynamic light scattering and flow birefringence. It was established that this process results in the formation of stable aggregates of selenium nanoparticles that adsorb BSA molecules. It was found that highly-ordered superhigh-molecular-weight spherical nanostructures with high density and unique morphology are formed. Experiments with a cell culture of promyelocytic leukemia HL-60 showed that BSA adsorbed on selenium nanoparticles can inhibit the growth of tumor cells and deactivate free radicals with an efficiency comparable with that of sodium selenite. |
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