Synthesis of bicyclic gamma-ylidenetetronates |
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| Authors: | Velázquez Francisco Olivo Horacio F |
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| Affiliation: | Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City 52242, USA. |
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| Abstract: | ![]()
The bicyclic gamma-ylidenetetronate motif found in several Stemona alkaloids was prepared in a stereoselective manner by addition of lithium methyl tetronate to an alkoxy oxonium ion formed from a lactone. The corresponding mixed alkyl ketal obtained was subjected to a Lewis acid-base-promoted dealkoxylation reaction to deliver the desired products. |
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