Crystal Structure and Conformation of 2'-C-Ethoxy- 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)uridine |
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| Authors: | CHI Guo-Chen CHEN Ru-Yu |
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| Institution: | 1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
2. Central Laboratory, Nankai University, Tianjin 300071, China |
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| Abstract: | The title compound, C23H42N2O8Si2, Mr=530.77, crystallizes in the monoclinic system, space group P21, with a=10.577(5), b=10.528(2), c=13.374(5)?, (=100.63(3)(, V=1461(2)?3, Z=2, Dx=1.207g/cm3, ((MoK()=0.71073?, (=1.590mm-1, T=299(1K, F(000)=572, R=0.070 and Rw=0.075 for 1232 observed reflections with I (3((I). The analysis result indicates that the configuration of the title compound at C(2() is S. In the crystal state the molecule has anti- conformation about glycosidic bond with the torsion angle -126.96(. The sugar ring is puckered with C3(-endo-C4(-exo, and the conformation of the C(4()-C(5() bond is +sc. |
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| Keywords: | nucleosides ketonucleosides semi-ketal conformation |
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