Catalyst-free one-pot synthesis of 1,4,5-trisubstituted pyrazoles in 2,2,2-trifluoroethanol |
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| Authors: | Heshmatollah Alinezhad Mahmood Tajbakhsh Mahboobeh Zare |
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| Affiliation: | Faculty of Chemistry, Mazandaran University, Babolsar, Iran |
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| Abstract: | ![]()
A simple, efficient and three component one-pot synthesis of 1,4,5-trisubstituted pyrazoles by condensation of β-dicarbonyls, N,N-dimethylformamide dimethyl acetal (DMFDMA) and hydrazine derivatives in 2,2,2-trifluoroethanol without using any catalyst and activation, is described. |
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| Keywords: | 2,2,2-Trifluoroethanol Pyrazole Cyclization Enaminone |
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