A new ent-clerodane diterpenoid from Crassocephalum bauchiense Huch. (Asteraceae) |
| |
| Authors: | Alembert T Tchinda Simplice R Mouokeu Rosalie AN Ngono Madeleine RE Ebelle Aristide LK Mokale Diane K Nono |
| |
| Institution: | 1. Institute of Medical Research and Medicinal Plant Studies, (IMPM), P.O. Box 6163, Yaoundé, Cameroonalembertt2002@yahoo.fr;3. Institute of Fisheries and Aquatic Sciences, University of Douala, PO Box 2701, Douala, Cameroon;4. Department of Biochemistry, Faculty of Science, University of Douala, PO Box 24157, Douala, Cameroon;5. Institute of Medical Research and Medicinal Plant Studies, (IMPM), P.O. Box 6163, Yaoundé, Cameroon;6. Department of Biochemistry, Faculty of Science, University of Douala, PO Box 24157, Douala, Cameroon |
| |
| Abstract: | A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in the isolation of a new clerodane diterpenoid, ent-2β,18,19-trihydroxycleroda-3,13-dien-16,15-olide (1), together with two known flavonoids 3′,5-dihydroxy-4′,5′,6,7,8-pentamethoxyflavone (2) and 4′,5-dihydroxy-3′,5′,6,7,8-pentamethoxyflavone (3). The compounds were tested against the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Compound 2 showed weak activity (IC50 = 10.1 g/mL) whilst compounds 1 and 3 were inactive. The structures of the compounds were elucidated by using detailed spectral analyses, especially 1H and 13C NMR, 1H–1H COSY, NOESY, HMBC and HR-ESI-MS. |
| |
| Keywords: | Crassocephalum bauchiense Asteraceae clerodane diterpenoid flavonoids antiplasmodial activity |
|
|
