Butyrolactones derivatives from the fermentation products of a plant entophytic fungus Penicillium oxalicum |
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| Authors: | Lin Yuan Wenzhong Huang Kun Zhou Yuede Wang Wei Dong Gang Du |
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| Institution: | 1. Chemical Science and Technology Department, Kunming University, Kunming, 650214, P.R. China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &3. Ministry of Education, Yunnan University of Nationalities, 650031, P.R. China |
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| Abstract: | Two new butyrolactone derivatives, terrelactones A and B (1 and 2), together with four known butyrolactone derivatives (3–6), were isolated from the fermentation products of the fungus Penicillium oxalicum 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1 and 2 were evaluated. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 25.5% and 27.4%, respectively. The inhibition rate is close to that of positive control (28.9%). |
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| Keywords: | butyrolactone derivatives Penicillium oxalicum 0403 anti-TMV activities |
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