Two new eudesmane-type glucopyranosides from the fruits of Daucus carota L. |
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| Authors: | Jin-Ke Xu Xiang-Hong Lu Wei Zhu Bing-Xian Yang Lin Zhang |
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| Institution: | 1. Shandong Center for Disease Control and Prevention, Jinan 250014, P.R. China;2. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P.R. China;3. Lishui People's Hospital, Lishui 32300, P.R. China;4. The Key Laboratory of Biomedical Engineering, Department of Biomedical Engineering, Zhejiang University, Ministry of Education, Hangzhou 310027, P.R. China |
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| Abstract: | Two new eudesmane-type glucopyranosides have been isolated from the fruits of Daucus carota L. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as daucucarotol-10-O-β-d-glucopyranoside (1) and decahydro-7-(2-O-β-d-glucopyranosyl)-isopropyl]-1β,4aα-dimethyl-(1α,4α,8aβ)-naphthalenetriol (2). Compounds 1 and 2 showed moderate antitumour activity against human ECA-109 and gave IC50 values of 23.22 and 26.76 μM, respectively. |
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| Keywords: | Daucus carota L eudesmane type sesquiterpene glycoside antitumour activity |
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