| 壳聚糖基质与蛋白质药物的释放 |
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| 引用本文： | 孙庆申,车小琼,赵凯.壳聚糖基质与蛋白质药物的释放[J].高分子通报,2008(6). |
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| 作者姓名： | 孙庆申 车小琼 赵凯 |
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| 作者单位： | 黑龙江大学生命科学学院,微生物黑龙江省高校重点实验室,哈尔滨,150080 |
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| 基金项目： | 黑龙江大学校科研和教改项目
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黑龙江省青年科学技术专项
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黑龙江省教育厅科学技术研究项目
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哈尔滨市青年科技创新人才基金
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黑龙江大学博士启动资金资助项目 |
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| 摘 要： | 为了达到治疗的目的,很多蛋白质药物正在被广泛地研究,但是目前蛋白质药物仍然存在着很多问题,如容易变性,被蛋白酶降解而失去疗效等等。如果使用合适的药物载体,就可以保护蛋白质药物不被酶降解并能控制药物的释放,达到缓释或者控释的目的,这将有助于延长药物在体内的生物活性。壳聚糖作为天然的生物大分子,被广泛地应用在生物材料、制药工业和医疗卫生领域中。本文主要介绍了壳聚糖基质具有适合作为药物缓释载体的特性,并分析了影响药物包封率和微球释放药物速率的因素。
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| 关 键 词： | 蛋白质 壳聚糖 微球 包封率 释放性能 |
Chitosan Matrix and the Release of Protein-derived Drugs |
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| SUN Qing-shen,CHE Xiao-qiong,ZHAO Kai.Chitosan Matrix and the Release of Protein-derived Drugs[J].Polymer Bulletin,2008(6). |
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| Authors: | SUN Qing-shen CHE Xiao-qiong ZHAO Kai |
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| Abstract: | Many protein-derived drugs are studied extensively in order to realize the therapeutic aims.However,protein-derived drugs have such disadvantages as easy to be denatured,degradation by proteinase and loss of functions.The application of suitable vectors may preserve the peptide and protein-derived drugs from being degraded by enzymes and control the release of the drugs,realizing the purpose of sustained or controlled release,which may help to prolong the bioactivities of the drugs in vivo.As a kind of natural biomacromolecules,chitosan has been used widely in biomaterials,pharmaceuticals and hygiene.This paper reviewed the features of chitosan as sustained-release vector,and analyzed the factors affecting encapsulating rate and drug release rate. |
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| Keywords: | Protein Chitosan Microsphere Encapsulation rate Drug-release features |
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