Thermal decomposition of some analgesic agents |
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| Authors: | Y. A. Ribeiro J. D. S. de Oliveira M. I. G. Leles S. A. Juiz M. Ionashiro |
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| Affiliation: | (1) Faculdade de Ciéncias Farmacéuticas, Universidade Estadual Paulista, 14801-902 Araraquara, SÃo Paulo, C. P. 502, CEP;(2) Instituto de Química, Universidade Estadual Paulista, 14800-900 Araraquara, SÃo Paulo, C. P. 355, CEP, Brazil |
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| Abstract: | ![]()
Thermogravimetry, derivative thermogravimetry (TG, DTG) and differential scanning calorimetry (DSC), were used to study the thermal behaviour of mefenamic acid, ibuprofen, acetaminophen, sodium diclofenac, phenylbutazone, dipyrone and salicylamide. The results led to thermal stability data and also to the interpretation concerning the thermal decomposition.The authors thank the FAPESP (Proc. 90/2933-4) and Biogalenica Quimica e Farmaceutica Ltda, Merrel Lepetit Farmaceutica Ltda, Roche Quimicos e Farmaceuticos S.A., Rhodia S.A. and Aché Laboratorios Farmaceuticos S.A., for supplying the analgesic agents. |
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| Keywords: | acetaminophen dipyrone ibuprofen mefenamic acid phenylbutazone salicylamide sodium diclofenac thermal decomposition |
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