Phytochemical investigation of Euphorbia trigona |
| |
Authors: | Vijayalekshmi Anju Koranappallil Bahuleyan Rameshkumar |
| |
Institution: | Phytochemistry and Phytopharmacology Division, KSCSTE-Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Pacha-Palode, Thiruvananthapuram, 695 562, Kerala, India |
| |
Abstract: | Euphorbia species (Family: Euphorbeaceae) have wide applicability in traditional medicines and biofuel sector, and are also rich sources of secondary metabolites, especially terpenoids, attributed with various pharmacological properties. Though 82 Euphorbia species are reported in India, most of the species are uninvestigated for their constituents or potential utilities. Present study reports the isolation and characterization of chemical constituents, estimation of major triterpenoids using a validated HPTLC method and cytotoxicity of plant and latex extracts of Euphorbia trigona. As the secondary metabolites epi-friedelinyl acetate, 3β-friedelinol, taraxerol, rhoiptlenone, stigmasterol and stearic acid were isolated and characterized from E. trigona. HPTLC estimation showed 3β-friedelinol at 0.91 ?± ?0.11% and taraxerol at 1.45 ?± ?0.12% was present in E. trigona plant powder (dry weight). Plant and latex extracts were found non toxic towards normal cell line H9C2 (cardiac myoblasts) and showed insignificant cytotoxic effects towards HeLa (cervical cancer cell line) upto 100 ?μg/ml concentration. |
| |
Keywords: | Triterpenoids 3β-friedelinol Taraxerol HPTLC Cytotoxicity |
本文献已被 ScienceDirect 等数据库收录! |
|