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| 用碳-13核磁共振法测定加纳霉胺的Pka值 | |
| 引用本文： | 高晓菊,刘树勋. 用碳-13核磁共振法测定加纳霉胺的Pka值[J]. 波谱学杂志, 1983, 1(1): 123-126 |
| 作者姓名： | 高晓菊 刘树勋 |
| 作者单位： | 1. 同济大学;2. 中国科学院上海药物研究所 |
| 摘 要： | 加纳霉胺是一种氨基糖甙,它具有生物活性。本品天然丰度的碳-13的化学位移随测定溶液的酸度而变化,观测的化学位移值是氢离子浓度的函数。本文对δc=f[H+]的实验结果采用非线性回归,曲线拟合的电算程序,求出加纳糖的解高常数Pka值,其Pk1=5.45,Pk2=6.75,Pk3=8.70。这种热动态参数为进一步研究氨基供了糖甙的代谢过程提可靠的理论依据。 |
| 收稿时间： | 1983-02-25 |
DETERMINATION OF GARAMINE PKa BY CARBON-13 NUCLEAR MAGNETIC RESONANCE |
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| Gao Xiaoju,Liu Shuxun. DETERMINATION OF GARAMINE PKa BY CARBON-13 NUCLEAR MAGNETIC RESONANCE[J]. Chinese Journal of Magnetic Resonance, 1983, 1(1): 123-126 | |
| Authors: | Gao Xiaoju Liu Shuxun |
| Affiliation: | 1. Tung-ji University;2. Shanghai Institute of Materia Medica, Academia Sinica |
| Abstract: | Garamine is an aminoglycoside with biological activity Its PKa values where determined over the PH range 2-13 by C-13NMR method. Data obtained in the experiment were analyzed by nonlinear regression method.Three PKa values have been obtained:PK1=5.45. PK2=6.75, PK3=8.70. The present information can provide a basis for further study of metabolism of aminoglyco -sides in livnig body. |
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