抗脂解活性的人参十四肽的结构预测

本文对抗脂解活性的人参多肽的结构进行了分析. 在一级结构的基础上预测了其二级结构含有较多的α螺旋, 后接一段无规卷曲. 应用分子力学方法, 结合晶体数据库信息, 计算了人参中抗脂解十四肽分子的相对构家能量和原子坐标, 模拟了构象能量优化过程, 得到了可能的最低能量构象. 并利用计算机分子图形技术建立了相应的人参抗脂解十四肽的三维分子模型. 模型的空间结构表明构象分析结果与二级预测的结论很好地相符。

Structural Prediction on the Anti-lipolytic Polypeptide of Ginseng

In this paper, the structure of the anti-lipolytic 14 peptides of Ginseng was studied. Based on the primary structure, the secondary structure was predicted to be mainly a helicity segment which linked a short coil region. We computed the relative conformational energy and the atomic coordinate of Ginseug polypeptide, simulated the optimizing process of conformational energy, obtained the possible energy-minimized conformation by means of molecular mechanics combined with the information from crystallographic database. We also built the corresponding three-dimension model of the Ginseng polypeptide. We also built the corresponding three-dimension model of the Ginseng polypeptide. The stereo structure of the model indicated that the result of the conformation analysis corresponded to the conclusion of the secondary structure prediction.Ginseng is a renowned and precious medico-botanical which contains many ...