Design of OFF/ON fluorescent thiol probes based on coumarin fluorophore |
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Authors: | Wei Sun Jing Li WenHua Li LiJuan Su LuPei Du MinYong Li |
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Institution: | 1. Key Laboratory of Chemical Biology of Natural Products (MOE); Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, 250012, China
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Abstract: | This paper presents a series of first- and second-generation click-modified coumarin-based fluorescent probes for thiols. These molecules demonstrate high turn-on fluorescent response and good selectivity towards aromatic thiols over other relevant reactive sulfur species, reactive oxygen species and common nucleophiles. Moreover, probe 1a can detect thiols in the reduced rabbit plasma sample. Therefore, this approach provides a particularly impressive tool for detecting thiol in biological systems. |
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Keywords: | coumarin fluorescent probe aliphatic thiols thiophenols |
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