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| 2-(5-甲基-2-苯基-4-噁唑基)乙醇的合成工艺改进 | |
| 引用本文： | 谢兵,蔡小华,胡薇.2-(5-甲基-2-苯基-4-噁唑基)乙醇的合成工艺改进[J].化学研究,2005,16(4):21-23. |
| 作者姓名： | 谢兵 蔡小华 胡薇 |
| 作者单位： | 1. 贵州大学,精细化工研究开发中心教育部绿色农药和农业生物工程重点实验室,贵州,贵阳,550025;贵州民族学院,化学与环境科学学院,贵州,贵阳,550025 2. 贵州民族学院,化学与环境科学学院,贵州,贵阳,550025 3. 南昌大学,分析测试中心,江西,南昌,330027 |
| 摘 要： | 以L-天门冬氨酸为原料,经过β-甲酯化,苯甲酰化,Dak in-W est反应,环合和氢化铝锂还原等反应步骤,以36.1%的总收率得到抗糖尿病药物的重要中间体2-(5-甲基-2-苯基-4-噁唑基)乙醇.用浓硫酸取代三氯氧磷作为关环剂,简化了环合工艺和后处理操作. |
| 关 键 词： | L-天门冬氨酸 Dakin-West反应 2-(5-甲基-2-苯基-4-噁唑基)乙醇 |
| 文章编号： | 1008-1011（2005）04-0021-03 |
| 收稿时间： | 2005-07-24 |
| 修稿时间： | 2005年7月24日 |
Improvement on Synthesis of 2-( 5-Methyl-2- phenyl-4- oxazolyl) ethanol |
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| XIE Bing,CAI Xiao-hua,HU Wei.Improvement on Synthesis of 2-( 5-Methyl-2- phenyl-4- oxazolyl) ethanol[J].Chemical Research,2005,16(4):21-23. | |
| Authors: | XIE Bing CAI Xiao-hua HU Wei |
| Abstract: | 2-(5-Methyl-2-phenyl-4-oxazolyl)ethanol was synthesized with a total yield of 36.1% from L-aspartic acid by 5-stepreactions,including β-esterification,N-benzoylation,Dakin-West reaction,cyclization and reduction using LiAlH_(4).Concentrated H_(2)SO_(4)was used as reagent for cyclizationinstead of toxic POCl_(3),and the procedure for cyclizationand its work-up were simplifed. |
| Keywords: | L-aspartic acid Dakin-West reaction 2-(5-methyl-2-phenyl-4-oxazolyl)ethanol |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |