A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides |
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| Authors: | Frederick Michael O Mulder Jason A Tracey Michael R Hsung Richard P Huang Jian Kurtz Kimberly C M Shen Lichun Douglas Christopher J |
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| Institution: | Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. |
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| Abstract: | A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides. |
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