酸性功能化离子液体催化“一锅法”合成酰胺烷基萘酚

用磺酸型离子液体1-甲基-3-磺酸丙基咪唑硫酸氢盐([MIMPS][HSO₄])催化β-萘酚、芳香醛和酰胺（或脲）3组分“一锅法” 类Ritter反应合成了酰胺烷基萘酚。 投料比为n(β-萘酚)∶n(芳香醛)∶n(酰胺或脲)∶n([MIMPS][HSO₄])=1∶1∶1.3∶0.1,无需溶剂，恒温125 ℃反应5～40 min，通过简单水洗抽滤即可分离产物，酰胺烷基萘酚产率为85%～97%。 离子液体[MIMPS][HSO₄]可回收重复使用4次，其催化活性无明显降低。 探讨了醛、酰胺或脲结构对反应的影响及可能的反应机理。

Synthesis of Amidoalkyl Naphthols:"One-pot" Reaction Catalyzed by Sulfonic Acid Ionic Liquid

An efficient one pot synthesis of amidoalkyl naphthols is described. This involves the three-component Ritter-type reaction of β-naphthol, aromatic aldehyde and amide or urea catalyzed by sulfonic ionic liquid, 1-methyl-3-propanesulfonic acid immidazolium hydrogen sulfate [MIMPS][HSO₄]. The results show that under solvent free condition at 125 ℃ and n(β-naphthol)∶n(aromatic aldehyde)∶n(amide or urea)∶n([MIMPS][HSO₄])=1∶1∶1.3∶0.1 for 5～40 min, the yield of amidoalkyl naphthols was 85%～97%. The product could be separated simply by filtration after the reaction. The ionic liquid was recycled four times without apparent decrease in catalytic activity. The factors which influenced the multi-component reaction were discussed including the structure of aromatic aldehyde and amide or urea. A possible mechanism was postulated as well.