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Resveratrol still has something to say about aging!
Authors:Quideau Stéphane  Deffieux Denis  Pouységu Laurent
Affiliation:Univ. Bordeaux, Institut des Sciences Moléculaires & Institut Européen de Chimie et Biologie, Pessac, France. s.quideau@iecb.u-bordeaux.fr
Abstract:
A votre Santé! The mechanism by which resveratrol, a hydroxystilbenoid polyphenol found in grapes and present in wine, exerts antiaging metabolic benefits has been uncovered. Chung and co-workers have found that it works by inhibiting cAMP phosphodiesterases, thus triggering a signaling cascade that leads to the possible activation of the mammalian enzyme sirtuin?1.
Keywords:enzymes  natural products  plant polyphenols  resveratrol  sirtuins
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