| Synthesis of a Novel Series of S-Alkyl Thiobenzoate Compounds as Farnesyltransferase Inhibitors |
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| 作者姓名： | ShengBiaoWAN JunFENG FengMingCHU ZongRuGUO |
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| 作者单位： | DepartmentofMedicinalChemistry,InstituteofMateriaMedica,ChineseAcademyofMedicalSciences＆PekingUnionMedicalCollege,Beijing100050 |
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| 摘 要： | S-akyl thiobenzoate compounds were designed as farnesyltransferase (FTase) inhibitors. An effective synthetic method was explored. The structures of the target compounds were elucidated by NMR spectral and elemental analysis.
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| 关 键 词： | S-烷基硫代苯甲酸 抑制剂 法呢基转移酶 合成方法 苯并二氮杂草 麻醉剂 |
Synthesis of a Novel Series of S-Alkyl Thiobenzoate Compounds as Farnesyltransferase Inhibitors |
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| ShengBiaoWAN JunFENG FengMingCHU ZongRuGUO.Synthesis of a Novel Series of S-Alkyl Thiobenzoate Compounds as Farnesyltransferase Inhibitors[J].Chinese Chemical Letters,2005,16(2):151-154. |
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| Authors: | Sheng Biao WAN Jun FENG Feng Ming CHU Zong Ru GUO? |
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| Institution: | Sheng Biao WAN,Jun FENG,Feng Ming CHU,Zong Ru GUO? Department of Medicinal Chemistry,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050 |
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| Abstract: | S-akyl thiobenzoate compounds were designed as farnesyltransferase (FTase) inhibitors.An effective synthetic method was explored. The structures of the target compounds wereelucidated by NMR spectral and elemental analysis. |
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| Keywords: | S-Akyl thiobenzoate compounds benzodiazepine farnesyltransferase |
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