草酸钙型尿结石病人结石和尿液微晶的形貌特征分析

泌尿系结石是临床上的常见病和多发病,可生长于肾盂、肾实质、输尿管以及膀胱中,较大的结石常会导致尿道阻塞、感染甚至肾脏坏死等病变,是一种严重危害人体健康的泌尿系统疾病。尿结石是动物体内异常生物矿化的产物,其主要成分有草酸钙、磷酸铵镁、尿酸等,其中以草酸钙最为常见。本研究直接取肾结石病人排出体外的自然结石和尿液中的结石微晶作为研究对象,采用透射电子显微镜、扫描电子显微镜、X-射线衍射分析和傅立叶变换红外光谱等手段对尿结石进行表征分析。研究结果表明,尿液中的纳米微晶的聚集是导致微晶快速增大和结石形成的关键因素,通过调控纳米微晶的物理化学性质有可能抑制肾结石的形成和复发。

Analysis of the Stones of Calcium Oxalate Urinary Stones Patients and Morphology of Urine Crystallites

Urinary calculus is a serious hazard to human health and diseases of urinary system in clinic. It can be grown in the renal pelvis, renal, ureter and bladder, the larger stones often lead to obstruction of the urinary tract, infection or necrosis of the kidneys and other diseases. Urinary calculus is a product of the animal abnormal biomineralization, its main ingredients are calcium oxalate, magnesium ammonium phosphate and uric acid. Calcium oxalate is the most common of one which. In this study, direct access to the patient with renal stones excreted in urine of natural stone and stone microcrystal, using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X- ray diffraction (XRD) and Fu Liye transform infrared spectroscopy (FT-IR) and other methods were used to characterize the urinary calculus. It is concluded that agglomeration of urinary nanocrystallites is a key factor leading to rapid growth of the crystallites and formation of urinary stones. Through the regulation of physical and chemical properties of nanocrystallites, the formation and recurrence of urinary stones are possible inhibited.