Facile synthesis of 2-(phenylthio)phenols by copper(I)-catalyzed tandem transformation of C-S coupling/C-H functionalization |
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Authors: | Xu Runsheng Wan Jie-Ping Mao Hui Pan Yuanjiang |
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Institution: | Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, PR China. |
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Abstract: | 2-(Phenylthio)phenols were successfully synthesized from simple phenols and aromatic halides by using dimethyl sulfoxide as the oxidant. The transformation was accomplished via tandem copper(I)-catalyzed C-S coupling/C-H functionalization employing the CuI/L L = (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one] catalyst system. The mechanism of the reaction was elucidated based on an isotope labeling strategy. |
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