Convenient one-pot synthesis of thiobarbituro-quinoline derivatives via catalyst-free multicomponent reactions in water |
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| Authors: | Dulin Kong Qinghe Wang Zhongxiang Zhu Xianghui Wang Zaifeng Shi Qiang Lin Mingshu Wu |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571199, Hainan Province, PR China;2. Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China;3. Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158, PR China |
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| Abstract: | A one-pot, three-component condensation reaction of 8-quinolinol, 2-thiobarbituric acid and isatins or aldehydes in water to give novel barbituroquinoline derivatives for the first time, is described. The reaction is free of catalysts and toxic solvents, operating under mild conditions and allows for ease of product isolation, making it more environmentally friendly and suitable for large-scale operations. |
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| Keywords: | 2-Thiobarbituric acid 8-Quinolinol Synthesis Water |
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