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Synthesis of sulfonamides from azoles and sodium sulfinates at ambient temperature
Authors:Lili Fu  Xiaodong Bao  Shanshan Li  Lingtian Wang  Zhiguo Liu  Wanzhi Chen  Qinqin Xia  Guang Liang
Institution:1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China;2. Department of Chemistry, Zhejiang University, Hangzhou, 310028, China;3. School of Medicine, Shandong University, Jinan, 250012, China
Abstract:NBS or NIS mediated direct S/>N bond formation between azoles and sodium sulfinates is described. The reaction shows good substrate scope and tolerates a wide range of functionalities in both azoles and sodium sulfinate substrates. Pyrazoles are also suitable for this method, various 4-halopyrazoles derivatives were obtained by using <em>N</em>-halosuccinimide (NXS) as the halogen source.</td>
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Keywords:Synthetic methods  Sodium sulfinates  Azoles  Sulfonylation  Halogenation
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