|
|||||
|
|
Practical synthesis of latent disarmed S-2-(2-propylthio)benzyl glycosides for interrupted Pummerer reaction mediated glycosylation |
|
| Authors: | Yang Xu Qian Zhang Ying Xiao Pinru Wu Wei Chen Zejin Song Xiong Xiao Lingkui Meng Jing Zeng Qian Wan |
| Affiliation: | 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China;2. Institute of Brain Research, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei 430030, China |
| Abstract: | Practical synthetic methods to latent disarmed S-2-(2-propylthio)benzyl (SPTB) glycosides for interrupted Pummerer reaction mediated glycosylation have been discovered. Among them, both coupling reaction of PTB-Cl with glycosyl thiols and BF3·OEt2 promoted reaction of peracylated glycosides with PTB-SH produced peracylated SPTB glycosides in large scales and with high efficiency. |
| Keywords: | Interrupted Pummerer reaction Thioglycoside Disarmed glycoside Glycosyl donor |
| 本文献已被 ScienceDirect 等数据库收录！ | |