One-pot copper-catalyzed synthesis of 2-substituted benzothiazoles from 2-iodoanilines,benzyl chlorides and elemental sulfur |
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| Authors: | Zhao Yang Renhe Hu Xiaotong Li Xin Wang Ren Gu Shiqing Han |
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| Institution: | 1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai 200032, China |
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| Abstract: | An efficient one-pot three-component reaction of 2-iodoanilines, benzyl chlorides and elemental sulfur to form 2-substituted benzothiazoles in satisfactory yields (up to 98%) has been described. The reaction tolerated a wide range of functional groups on the aromatic ring. And heterocycle methylene chlorides substrates were also found to be compatible. |
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| Keywords: | One-pot Copper-catalyzed Benzyl chloride 2-Substituted benzothiazoles |
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