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Jaspamides M-P: new tryptophan modified jaspamide derivatives from the sponge Jaspis splendans |
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| Authors: | Fulvio Gala Simona De Marino Franco Zollo Staci N Keller |
| Institution: | a Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli ‘Federico II’, via D. Montesano 49, 80131 Napoli, Italy b Department of Pharmaceutical Sciences, Medical University of South Carolina, 280 Calhoun Street, Box 250140, Charleston, SC 29451, USA |
| Abstract: | Four new jaspamide derivatives with antimicrofilament activity were isolated from the marine sponge Jaspis splendans. Their structures were elucidated by NMR and MS analysis. A structure-activity relationship analysis on all natural jaspamides is also reported here. |
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