New cytotoxic spongian diterpenes from the sponge Dysidea cf. arenaria |
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| Authors: | Mika Agena Novriyandi Hanif Junichi Tanaka |
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| Institution: | a Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan
b Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan |
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| Abstract: | Seven new (1-7) and three known (8-10) spongian-class diterpenes have been isolated from the sponge Dysidea cf. arenaria collected in Okinawa. Compound 6 was also isolated from the nudibranch Chromodoris kuniei. The structures of the new entities were elucidated by spectroscopic analyses. Three of the new spongians (2, 6, and 7) showed cytotoxicity against NBT-T2 rat bladder epithelial cells. |
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| Keywords: | Marine natural products Sponge Diterpene Cytotoxicity |
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