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Shahidine, a novel and highly labile oxazoline from Aegle marmelos: the parent compound of aegeline and related amides |
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| Authors: | Shaheen Faizi Fatima Farooqi Aneela Naz Farheen Ansari Shakeel Ahmed Khan |
| Affiliation: | a H.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan b Department of Chemistry, University of Karachi, Karachi-75270, Pakistan c Department of Microbiology, University of Karachi, Karachi-75270, Pakistan |
| Abstract: | A rare alkaloid, shahidine (1), having an unstable oxazoline core has been isolated as a major constituent from the fresh leaves of Aegle marmelos. It is moisture-sensitive, and found to be the parent compound of aegeline and other amides, however, it is stable in dimethyl sulfoxide. Its structure was established by spectroscopic analysis. Biogenetically, oxazolines may be considered as the precursor of hydroxy amides and oxazoles found in plants. Shahidine (1) showed activity against a few Gram-positive bacteria. |
| Keywords: | Aegle marmelos Oxazoline Amides Antibacterial activity |
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