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Preparation and physical characterization of forms II and III of paracetamol |
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| Authors: | P. Di Martino P. Conflant M. Drache J. -P. Huvenne A. -M. Guyot-Hermann |
| Affiliation: | 1. Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille II, 1, rue du Professeur Laguesse B.P. 83, 59006, Lille Cedex 2. URA CNRS 452, Laboratoire de Cristallochimie et Physicochimie du Solide, Ecole Nationale Supérieure de Chimie de Lille, Université des Sciences et Technologies de Lille, France 3. LASIR CNRS USTL, Laboratoire de Spectrochimie Infrarouge et Raman, Université des Sciences et Technologies de Lille, France |
| Abstract: | The polymorphic forms II and III of paracetamol were obtained by melting the marketed form I. Under the melting and cooling conditions used, it was possible to obtain forms I, II and III. The recrystallization conditions and the physical properties of forms II and III were investigated by means of various techniques: thermomicroscopy, DSC analysis, infrared microspectrometry and X-ray powder diffraction at room temperature and as a function of temperature. Form III was found to be very unstable. However, its formation seems to be an important intermediate step in the preparation of form II. |
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