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| 单一分布聚乙二醇的合成及其应用 | |
| 引用本文： | 冯柏成,赵金铠,管宪文.单一分布聚乙二醇的合成及其应用[J].高分子通报,2010(5). |
| 作者姓名： | 冯柏成 赵金铠 管宪文 |
| 作者单位： | 1. 青岛科技大学化工学院,青岛,266042 2. 青岛迪爱生精细化学有限公司,青岛,266101 3. 青岛润兴光电材料有限公司,青岛,266024 |
| 摘 要： | 聚乙二醇(PEG)经过对端基官能团化接枝到药物等生物活性分子上后,可提高药物等的水溶性、抗免疫原性、生物相容性和稳定性并降低毒性。工业级聚乙二醇由于杂质含量高尤其是其中二醇的含量过高、分子量分布过宽,不能直接用于药物等的改性。除利用聚合方法制备窄分布高纯度的聚乙二醇外,采用有机合成方法合成单一聚乙二醇链是有效的手段。对"单一链长(discrete length)"或者"单一分布(mono-disperse)"的聚乙二醇高分子聚合物的近年来主要合成方法的进展进行了综述并简介了其主要应用。 |
| 关 键 词： | 聚乙二醇 单一分布 官能团化 |
Synthesis of Mono-disperse Polyethylene Glycol and its Application |
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| FENG Bai-cheng,ZHAO Jin-kai,GUAN Xian-wen.Synthesis of Mono-disperse Polyethylene Glycol and its Application[J].Polymer Bulletin,2010(5). | |
| Authors: | FENG Bai-cheng ZHAO Jin-kai GUAN Xian-wen |
| Institution: | 1.QingDao University of Science & Technology;Qingdao 266042;China;2.Qingdao DIC Finechemicals Co.;Ltd.;Qingdao 266101;3.Qingdao Runxing Photoelectric Material Co.;Qingdao 266024;China |
| Abstract: | Polyethylene glycol(PEG) can be conjugated to bioactive molecules after functionalization of the end groups,and then improve their water solubility,anti-immunogenicity,biocompatibility and stability,reduce the toxicity.However,industrial grade PEG can not be used in conjugation to medicines etc.due to high content of impurities,in particular high content of diol and wide polydispersity.Synthesis of single PEG chains was an effective approach to get suitable PEG molecules for conjugation besides preparation ... |
| Keywords: | Polyethylene glycol Mono-disperse Functionalization |
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