A three component one-pot synthesis of N-amino-2-pyridone derivatives catalyzed by KF-Al2O3 |
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Authors: | B Kshiar O R Shangpliang |
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Institution: | Department of Chemistry, North-Eastern Hill University, Shillong, Meghalaya, India |
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Abstract: | Synthesis of 1,6-diamino-4-phenyl-3,5-dicyano-2-pyridone derivatives via a one-pot, three-component reaction of aryl aldehydes, malononitrile, and cyanoacetic hydrazide at room temperature using KF-Al2O3 as a recyclable catalyst have been developed. The reaction proceeds through the initial Knoevenagel condensation between aldehyde and malononitrile in the presence of KF-Al2O3 to form the benzylidene derivative which then undergoes Michael addition with cyanoacetic hydrazide followed by intramolecular cyclization of the resulting intermediate to produce the N-amino-2-pyridones in good to excellent yields. The structure of the synthesized compounds were characterized and established on the basis of their spectral data analysis and single-crystal XRD analysis. |
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Keywords: | KF-Al2O3 multi-component reactions N-amino-2-pyridones |
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