One-pot multicomponent synthesis of novel thiazol-2-imines via microwave irradiation and their antifungal evaluation |
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| Authors: | Saba Kauser Jaweed Shaikh Shilpa M. Somagond Atulkumar A. Kamble Mahadev N. Kumbar |
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| Affiliation: | Department of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, India |
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| Abstract: | Microwave-assisted green approach is developed for an efficient synthesis of thiazol-2-imines under catalyst-free conditions. The desired products are formed by one-pot three-component reaction which is an improvised method for Hantzsch thiazole synthesis. The microwave-assisted protocol gives excellent yields with high purity in just 10–15?min. All the synthesized compounds have been screened for antifungal activity and some of the derivatives show a broad spectrum against fungal pathogens. |
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| Keywords: | 1,2,4-Triazolone antifungal activity green synthesis multicomponent reaction thiazol-2-imines |
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