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An overview on synthetic strategies to coumarins |
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| Authors: | M. A. Salem M. H. Helal M. A. Gouda Y. A. Ammar M. S. A. El-Gaby S. Y. Abbas |
| Affiliation: | 1. Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail Assir, KSA;2. Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt;3. Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt;4. Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, KSA;5. Department of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, KSA;6. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt;7. Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut, Egypt;8. Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt |
| Abstract: | Coumarins units have recently emerged as a hot topic of research due to their diverse applications. Their synthesis is partly based on classical methodologies such as Pechmann reaction or Knoevenagel condensation, but it also sparked the discovery of completely new pathways. In very recent years so-called vertically expanded coumarins were synthesized, effectively expanding the portfolio of existing architectures. This review serves as a guide through synthesis strategies to coumarins. |
| Keywords: | Baylis–Hillman coumarins Horner–Wadsworth–Emmons Knoevenagel Pechmann Perkin Umpolung reaction |