Tablet disintegration monitored by magnetic resonance imaging |
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Authors: | S Kwieciński M Weychert A Jasiński P Kulinowski I Wawer E Sieradzki |
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Institution: | 1. MRI Laboratory, Institute of Nuclear Physics, Radzikowskiego 152, 31-342, Kraków, Poland 2. Faculty of Pharmacy, The Medical University of Warsaw, Warsaw, Poland
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Abstract: | The disintegration of bromhexin tablets was monitored by magnetic resonance imaging. The fast imaging method FLASH with spoiling
gradients was used to obtain images of the tablets in short time intervals. The rate of the disintegration depends on the
preparation method, kind and percentage of the carrier (polyethylene glycol, lactose). Solid dispersion with slow evaporation
of solvent yields materials with decreased dissolution rate. Increasing molecular mass of polyethylene glycol and its percentage
content also hampers disintegration. |
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