| 用二维NMR交换谱定量地研究氘代DMSO和氘代氯仿中小肽活泼质子的交换动力学 |
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| 引用本文： | 杜琛,毛希安.用二维NMR交换谱定量地研究氘代DMSO和氘代氯仿中小肽活泼质子的交换动力学[J].波谱学杂志,1999,16(1):21-27. |
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| 作者姓名： | 杜琛 毛希安 |
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| 作者单位： | 中国科学院武汉物理与数学研究所, 波谱与原子分子物理国家重点实验室, 武汉 430071 |
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| 基金项目： | Project supported by the National Natural Science Foundation of China under the number of 29725307. |
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| 摘 要： | 用核磁共振二维交换谱方法研究了类肽化合物Cbz-Ser-Tyr-OC6H13中活泼质子的交换动力学,结果表明,在DMSO-d6和CDCl3溶液中,四种活泼质子与溶剂中残留水的交换快慢顺序为:Ser-OH > Tyr-OH > Ser-NH > Tyr-NH.在此基础上,对氨基酸中氨基所处的局部环境进行了讨论.
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| 关 键 词： | 二维交换谱 小肽 活泼质子 交换动力学 |
| 收稿时间： | 1998-11-02 |
QUANTITATIVE STUDY OF EXCHANGE DYNAMICS OF MOBILE PROTONS OF A SMALL PEPTIDE IN DMSO-d6 AND CDCl3 USING 2D EXSY |
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| Du Chen,Mao Xi'an.QUANTITATIVE STUDY OF EXCHANGE DYNAMICS OF MOBILE PROTONS OF A SMALL PEPTIDE IN DMSO-d6 AND CDCl3 USING 2D EXSY[J].Chinese Journal of Magnetic Resonance,1999,16(1):21-27. |
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| Authors: | Du Chen Mao Xi'an |
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| Institution: | State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071 |
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| Abstract: | NMR two dimensional (2D) exchange spectroscopy (EXSY) is used to study the exchange dynamics of mobile protons in a small pseudopeptide Cbz-Ser-Tyr-OC6H13. It is shown by a quantitative study that the exchange rates for the four mobile protons in this molecule with water are in the order Ser-OH～Tyr-OH>Ser-NH>Tyr-NH, under the given experimental conditions with dimethylsulfoxide and chloroform as solvents. Local structures for the amino groups in different solutions are described. |
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| Keywords: | NMR Proton Exchange Peptide Organic Solvents |
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