Ligand-free copper(I) catalyzed N- and O-arylation of aryl halides |
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| Authors: | Elena Sperotto Gerard P.M. van Klink |
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| Affiliation: | a Organic Chemistry and Catalysis, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
b DSM Research, Life Sciences, Advanced Synthesis and Catalysis, PO Box 18, 6160 MD Geleen, The Netherlands |
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| Abstract: | A simple and industrially viable protocol for C-N and C-O coupling is reported here. Arylation of phenol, benzylamine and imidazole with aryl bromides is achieved using ligand-free Cu(I) halide salts in low catalytic amount (2.5 mol %). |
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