A copper-catalyzed domino radical cyclization route to benzospiro-indolizidinepyrrolidinones |
| |
| Authors: | Christian V Stevens Ellen Van Meenen Yves Eeckhout Bart D’hondt Viktor V Zhdankin |
| |
| Institution: | a Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium
b Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN 55812, USA |
| |
| Abstract: | In this Letter the synthesis of benzospiro-indolizidinepyrrolidinones is described by a domino atom transfer radical cyclization reaction using a copper catalyst. The structure of one of the products was established by single crystal X-ray diffraction. The investigated precursors, bearing a homo allyl substituent on the N-indole, result in a 5-exo-trig, followed by a 6-endo-trig cyclization. When the N-indole is substituted with an allyl group, only the spiro-cyclization occurs. |
| |
| Keywords: | Cu(I)Cl Atom transfer radical cyclization ATRC Domino reaction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
