Rapid synthesis of 2,3-disubstituted-quinazolin-4-ones enhanced by microwave-assisted decomposition of formamide |
| |
| Authors: | Ioannis K Kostakis Elisabeth Seguin Thierry Besson |
| |
| Institution: | a UMR CNRS 6014, Groupe de Chimie Pharmaceutique, Université de Rouen, UFR Médecine-Pharmacie, 22 Boulevard Gambetta, F-76183 Rouen Cedex, France
b Milestone S.r.l., Via Fatebenefratelli, 1/5, 24010 Sorisole (BG), Italy |
| |
| Abstract: | An efficient methodology for the preparation of a series of 2,3-disubstituted-quinazolin-4(3H)-ones is described via a three step reaction from anthranilic acid. The obtained results also reveal that microwave-assisted rapid decomposition of formamide under controlled conditions of power, temperature and time is a very convenient source of ammonia for the synthesis of 2-substituted-quinazolin-4(3H)-ones and other rings. |
| |
| Keywords: | Microwave-assisted chemistry Quinazolin-4-ones Benzoxazin-4-ones Formamide |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
