Expeditious synthesis of indolizine derivatives via iodine mediated 5-endo-dig cyclization |
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| Authors: | Ikyon Kim Jihyun Choi Hye Kyoung Won Ge Hyeoung Lee |
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| Institution: | Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea |
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| Abstract: | Iodine-mediated 5-endo-dig cyclization of propargylic esters 2 at room temperature proceeded smoothly to give highly functionalized indolizines 3 in excellent yields. A pyridine group was employed as a nucleophilic partner in this facile process for the first time. |
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| Keywords: | Indolizine Iodine 5-endo-dig Cyclization Environmently benign |
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